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Clinical Research
As part of our commitment to advances and innovation in medicine, Bellevue Medical Center participates in the conduct of research in various fields, all of which are of the highest caliber, many of which are multi-centered and international. Below is a list of the clinical research trials ongoing at Bellevue Medical Center:


Uterine Factor Infertility (UFI) is a condition where a woman cannot carry a pregnancy because she was born without a uterus, or has a dysfunctional uterus (for e.g. from cancer or other disease). At least 100,000 women are estimated to be affected in MENAT by this type of infertility which is the only one lacking a treatment today.

At the Sahlengrenska Academy, the University of Gothenburg and the Sahlgrenska University Hospital in Sweden, a research project has been ongoing since 1999 which aims to provide women with the possibility of having biological children with the aid of a transplanted uterus. The Swedish research team accomplished its first birth in September 2014 and has performed a total of nine uterus transplants that have resulted in five pregnancies and four live births.

Bellevue Medical Center, renowned for its high quality standards, has been chosen by the Swedish team for an exclusive partnership in the Middle East/North Africa & Turkey Region, to perform the pioneer uterus transplant among the first worldwide centers.

Click HERE for more info.


A randomized double-blind, placebo-controlled study of LEEOll in combination with letrozole for the treatment of postmenopausal women with hormone receptor positive, HER2 negative, advanced breast cancer who received no prior therapy for advanced disease.


A phase III randomized , double blind, placebo controlled study of LEE011 or placebo in combination with tamoxifen and goserelin or a non-steroidal aromatase inhibitor (NSAI) and goserelin for the treatment of premenopausal women with hormone receptor positive, HER 2 negative, advanced breast cancer.
Click here for more details.

Condition/Illness Related Research Study Brief Summary Bellevue Medical Center Investigator
Advanced breast cancer CLEE011A2301 (Monaleesa 2) Randomized study for post-menopause women with no prior treatment. Dr. Fadi El Karak
Metastatic non-small cell lung cancer (NSCLC) CLDK378A2112 Randomized study for adults to compare efficacy and safety of treatment taken with different diets. Dr. Fadi El Karak
Relapsed or relapsed/refractory multiple myeloma CLBH589D2222 (PANORAMA 3) Randomized study for patients previously exposed to immune-modulatory agents to evaluate the safety and efficacy of 3 different regimens. Dr. Fadi El Karak
Advanced breast cancer CLEE011A2404 (COMPLEEMENT-1) Study to assess safety and efficacy of a hormonal therapy regimen in men and women with no prior hormonal therapy. Dr. Fadi El Karak
Chronic immune thrombocytopenia CETB115BIC02
Observational studyto evaluate treatment with Revolade. Dr. Fadi El Karak
 Advanced renal cell carcinoma CPZP034AIC04 (PARACHUTE) Prospective, non-interventional, observational study to assess past treatment. Dr. Fadi El Karak
Breast cancer CBYL719A2201 Random studyto assess 2 different treatments in postmenopausal women. Dr. Dany Abi Gerges
Chronic myelogenous leukemia CABL001A2301 Random study for patients previously treated with 2 or more tyrosine kinase inhibitors.  Dr. Dany Abi Gerges
Advanced or metastatic non-small cell lung cancer  (NSCLC) TAIL study Study to explore long-term safety and efficacy of an immunotherapy treatment in patients previously treated. Dr. Fadi El Karak
Type 2 diabetes LIRA PRIME Study to assess safety and efficacy of different treatments on top of metformin in patients with poorly controlled diabetes on metformin alone. Dr. Grace Abi Rizk
Type 2 diabetes SUSTAIN 8 Study to compare safety and efficacy of 2 different treatments on top of metformin. Dr. Georges Hajj
Acute heart failure AFFIRM-AHF Randomized study to compare safety, efficacy and outcomes of a new treatment vs. placebo in patients with iron deficiency anemia.  Dr. Ghassan Kiwan
 Venous thromboembolism (VTE)
Deep vein thrombosis (DVT)
 Pulmonary embolism (PE)
RE-COVERY Study to follow outcomes and compare safety and efficacy of a new vs. traditional treatment in preventing DVTs and PEs.  Dr. Ghassan Kiwan
Migraine EmPOWER Randomized study for adults comparing safety and efficacy of subcutaneous treatment vs. placebo. Dr. Souheil Gbeily
Metastatic colorectal cancer (mCRC) OPTIMISE Observational study to assess treatment. Dr. Fadi El Karak

For more information, please ask your physician or call Ext. 7600.